Thanks Charch,
"you also get a diplomacy bonus for having a trade route, so sometimes it can be worthwhile to send them races you have differing ideologies from just to help offset the negatives."
You know, that's the way it used to be, but I no longer see that listed as a plus in the Diplo pop-up when hovering over another Civ.
I still see things like Out of Travelling Range, Ripe for Conquering, Open Borders Treaty, etc, but no more mention of the Trade Routes. I don't know what's up with that.