My thoughts on this. Note that this isn't a 'do all of this', but just some ideas on 'fixing' mid-late game economy.
- Change Trade Ports to be 6 or even 8 logistics slots each. They're just way too 'strong' for how little of a footprint they have. Compare how effective just one trade port is, versus generally needing at least two orbital refinery structures to get any meaningful income from them. Addicionally, have any of you seen a planet with one or two +trade% bonuses, with five trade ports? I had one planet making around 50% of my total income!
- Remember the 'High Security Protocol' bonus? What if the more tactical structures you had, the less effective trade would be? Somehow I doubt traders would be happy about traversing a mine field just to drop off a load of bobblehead dolls.
- Destroying multiple trade / refinery ships along a route will 'disable' that route for a period of time, or at least limit it. For a period of time after cessation of attacks, no ships will utilize that route, with the resulting long-term impact on the economy in question.