So I started playing the beta today and noticed that there's performance hit as I uncover more and more of the galaxy - so basically, panning around is I would say a bit worse than in Civ V under similar circumstances.
There's quite a bit of disk churning as well (by which I mean that the hard disk light on my case is furiously flashing away, it's a very quiet drive) and transitioning to and from the planet and shipyard screens is slow.
After playing for a while, exiting to the desktop can make my computer slow to respond, I guess because there's more to unload from memory.
Okay that's it for now. Keep working on it, guys, it looks great!