I haven't played as many 4x games as some of you, but if I use 'willing to put some work into the game, to make it easier/more scenarios for me to play, by making handy references, scenarios, mods, etc. as one of my yardsticks, as well as how often I go back to said games...
Sid Meier's Alpha Centauri/Alien Crossfire - would love to see an updated version, as long as it stayed as true as possible to the original!
Ascendancy - made my own printable tech tree for this game, as the one I found online didn't have enough info for my tastes. Still holding out for a PC port of the new IOS version...
Pax Imperia (yes the old Mac game, not the Eminent Domain sequel for PC). Haven't found a PC port of the original game, so I haven't played it in a while... I do have Eminent Domain in a box somewhere, but it's not the same...
Galactic Civilizations II Darklords/Twilight - love the ship design feature! I feel very little need to tweak/mod the game, which is a compliment to the designers! Was playing TOA just yesterday...
Warlords III - Reign Of Heroes/Darklords Rising (don't play it as much these days as it won't work on my Vista machine despite numerout attempts to get it to work, I still have an XP laptop that I use specificallty to play this game when I get the itch).
BTW, in general I'm not a fan of non-turn based 4x games. I enjoyed Homeworld when I played it, but not enough to want to play it over and over. Warcraft wasn't bad either, but my reflexes aren't what they used to be. I enjoy pondering my decisions, not just making them on the fly.
Also, I got bored with the Civ franchise. SMAC/SMAX got a few additional concepts right IMHO, and I haven't been able to enjoy 'vanilla Civ' since (own 2 and 3 currently). I got Civ 4 for Christmas a while back, tried it, and then gave it away... Civ 5 has failed to interest me, mainly because learning a new way to do the same thing as the older games gets tedious after a while (this is why I ended up giving Civ 4 away). I'm just burned out on Civ in general, SMAC/SMAX excluded.
Elemental (E:WOM, E:FE E:LH) isn't quite where I'd like to see the game at this point. I enjoy it to a point, but a number of elements just aren't quite where I'd like to see them. So while I do like to play it every so often, it doesn't make my top 5. It is well designed at this point, but as I mentioned, just isn't quite to the point where I feel the need to play it all the time.
FreeOrion currently has my attention. Still very much in alpha/beta mode, but I like how the game is put together so far. I like it enough that I've made my own reference materials for it, to better understand the game.
Pandora - First Contact intrigues me, mainly because of SMAC/SMAX supposedly being a strong influence. I may or may not pick it up.