That might be even worse than expanding galaxies. Bear in mind that the nearest galaxy to our own, Andromeda, is millions of light-years away. In order to traverse the immense void between them in such a fashion your starships would need to have FTL engines so fast that they could instantaneously travel from one end of the Milky Way to the other, going outside the galaxy even at these tremendous speeds is very dangerous - what if you happen across a rogue star, satellite galaxy or other such object? You'd be ripped apart.
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Once again this is a game and even though in reality the nearest galaxy is Andromeda at 2.2 million light years away, doesn't mean that this has to be the case. Let's assume the galaxy is only 1,040 light years wide (in fact our galaxy is 100,000 - 120,000 light years wide) and the nearst galaxy is 10,400 light years away. Now assume in game we're able to cross the galaxy in 104 turns (which in galciv2 would mean it takes 2 years to cross at approx 502 times the speed of light). So now we try to cross the void (which does have other stellar objects orbiting galaxies here or there) to the nearest galaxy, that would take another 1,040 turns, you know that's far to long so you need to research other technologies to narrow this down...
Mind you this is all a game not reality using real numbers for everything would through the interface off, having sun's size match reality (which I was off on one of my previous posts as I was putting in volume not diameter) here are some numbers to think of.
- The sun is 109 times the size of Earth or 10 times the size of Jupiter.
- The solar system to the edge of the planet is about 10 light hours across, to the edge of the Ort Cloud is approx 2-4 light years.
- The Milky Way Galaxy is between 100,000 to 120,000 light years in diameter.
- The nearest galaxy is Adromeda at 2.2 million light years away (which is about 19 times wider than the galaxy) and moving closer to the Milky Way at a slow speed (in relative to galactic terms) of 670,000 miles per hour.
Long story short? It's technically possible if we believe that humans are special enough to skip a few thousand years of technological advancement in order to understand the mechanics and therefore replicate Precursor energy technologies on such a scale as would be required.
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Yes, I believe it could be in confines of the game, anything is possible as Stardock and the designers of the game have all the creative flexibility that they need creating a fictional game 