Save games can sometimes become corrupted, so whenever a new update comes along I tend to start a new game. They certainly might work, but I find it easier to start over to avoid any issues.
I also tend to start a new game after an update, especially during a Beta cycle, but now we are running into a problem with the updates being so automatic, now that GC is on Steam. It is getting a bit late in the Beta program and having an update pop in before you have finished a game can be very annoying. Hence, with the update to 0.81 I attempted reloading a game saved on 0.80 just to see how successful it would be. Yes, after many turns, it did crash, but I was able to reload it from the autosave prior to the CTD and have progressed much further into the game. Almost as if the crash I had had nothing to do with having started the game on 0.80. Also, since the update list didn't list any new features or functions it looked like 0.81 should be fully compatible with saves from 0.80.
Again, I did this as a test of what looked to me should have been a fully compatible situation, a situation that is bound to happen a lot after release.