Working in a huge galaxy, with all races as AI except Humans. Running 70 ships, 22 colonies, 5 ship yards, and seven starbases. At turn 195 I was going through the idles list (ships, shipyards, planets) when I got a CTD while adding a building to the planet's que. I managed to repeat this four times. It was usually the second or third planet each time.
I moved a ship, went to the planet where the music would stop, the mouse pointer would move but not respond to clicks. If I waited, or hit Exc, the game would just drop to the desktop. After reloading the game it would repeat this behavior. Since I was attempting to see the combat screen, I fought my way through this, saving after each action and reloading after each crash (about five in total) until turn 197. Then it refused to accept 100% production use to sponsored shipyards as not being idle.
I would like to point out that I've been working with the Beta since the first iteration and this is the first one giving me issues -- and only since turn 195 of the first run through. Very happy with the product so far.