I won't argue with Darvin that blocking a wormhole isn't easy. An enemy shows up at any moment, but you have your guys blasting away, more so if you have an Akkan to give the starbase some reach. But at the same time you can put 4 starbases around a star and, depending on how many stars are in the game, you can put them pretty close to the arrival point of an enemy force or even near your most valuable phase lane, where you can get the most out of your range and use SC to really chew em up first. If you have just one or two other stars, you can pile up the damage.
In any case, both require you to be ready for a punching match if you plan on assaulting mid-late game, especially against Vasari.
Happy hunting.