Since patching to 1.01 the time to boot the game up has gotten extremely long. I'm guessing 5-7 minutes after starting the program before I can load a game. In Quickplay view you can see it slowly reeling off a list of things that it's loading. For example: Loading map: 72 seconds. Loading mainscreen: 32 seconds. Loading candidate create screen: 25 seconds.
This is far longer than it takes to load up a highly complex game like Papyrus' NASCAR 2004 or a WW2 flight sim.